EXERCISE, EXERCISE TESTING and EXERCISE TRAINING
SEE ALSO – Pulmonary rehabilitation


GUIDELINE on EXERCISE TESTING:
ATS/ACCP Statement on cardiopulmonary exercise testing (2003). Am J Respir Crit Care Med, 167, 211–277.
ajrccm.atsjournals.org/cgi/reprint/167/2/211

ATS STATEMENT: Guidelines for the six-minute walk test (2002) Am J Respir Crit Care Med, 166: 111-117
ajrccm.atsjournals.org/cgi/content/full/166/1/111
• indications, practicalities, safety factors, interpretation of results


Aboussouan LS (2009) Mechanisms of exercise limitation and pulmonary rehabilitation for patients with neuromuscular disease. Chr Respir Dis, 6, 4, 231-49
crd.sagepub.com/cgi/content/abstract/6/4/231
• benefits of carefully-managed exercise training for neurological patients, including support from noninvasive ventilation, neuromuscular electrical stimulation, or diaphragm pacing

Aliverti A (2001) How and why exercise is impaired in COPD. Respiration, 68, 229-39
• high expiratory pressures may reduce venous return and limit exercise in COPD

Bandolier (2004) Physical activity reduces risk of cognitive decline, vol.130
www.jr2.ox.ac.uk/bandolier/booth/hliving/physcog.html
• exercise reduces the risk of cognitive decline

Bandolier (2004) Bone mass and exercise in women, vol.130
www.jr2.ox.ac.uk/bandolier/band68/b68-2.html
• exercise training programmes prevent or reverse bone loss of almost 1% per year

Bauldoff GS (1996) Home-based upper-arm exercise training for COPD. Heart Lung, 25, 288-94.
• upper arm training can reduce SOB

Behnke M, Wewel AR, Kirsten D et al (2005) Exercise training raises daily activity stronger than predicted from exercise capacity in patients with COPD. Respir Med, 99, 711-17
www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WWS-4F8TK5D-1&_user=10&_handle=V-WA-A-W-AD-MsSAYVA-UUW-U-AAVEVEBYUW-AAVDUDVZUW-YCUVBEWVU-AD-U&_fmt=summary&_coverDate=06%2F30%2F2005&_rdoc=7&_orig=browse&_srch=%23toc%237138%232005%23999009993%23594642!&_cdi=7138&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=eb0f836c06049c4496fc44a8c8246982
• exercise training increased activity significantly more than predicted from the gain in exercise capacity, implicating the importance of patient-centred factors

Billaut F (2010) Cerebral oxygenation decreases but does not impair performance during self-paced, strenuous exercise. Act Physiol, 198, 477-86

Bjψrnshave B, Korsgaard J (2005) Comparison of two different levels of physical training in patients with moderate to severe COPD. Lung, 183, 101-108
www.springerlink.com/(ign225bp0skgvhar5wfhp4z0)/app/home/contribution.asp?referrer=parent&backto=issue,3,6;journal,3,52;browsepublicationsresults,1643,2517
• minimum training necessary to improve physical performance is 2–3 hours a week of middle intensity homebased training,

Bjφrnstad H et al (2001) Recommendations for exercise training in chronic heart failure patients. Eur Heart J, 22, 2, 125-135
eurheartj.oxfordjournals.org/content/22/2/125.full.pdf+html

Brooks D, Solway S (2006) Should the endurance shuttle walk test replace the six-minute walk test in individuals with COPD? Chron Respir Dis, 3, 1-2
• endurance test is very responsive but requires four tests which may cause excessive fatigue and be too time-consuming in practice.

Carrieri-Kohlman V et al (2001) Dyspnea and the affective response during exercise training in obstructive pulmonary disease. Nurs Res, 50, 136
• exercise reduces anxiety related to breathlessness

Cesari M (2004) Antioxidants and physical performance in elderly persons. Am J Clin Nutr, 79, 289-94
• higher dietary intakes of most antioxidants, especially vitamin C, is associated with higher skeletal muscular strength in elderly persons

Clark CJ (1996) Low intensity peripheral muscle conditioning improves exercise tolerance and breathlessness in COPD. Eur Resp J, 9, 2590-6.
• details of exercises,
• outcomes: increased fitness, reduced SOB, on-going self-management

Collins E (2004) Effects of exercise training on aerobic capacity and quality of life in individuals with heart failure. Heart Lung, 33, 3, 154-61
• exercise training in adults with heart failure increases exercise tolerance and perceived physical function

Collins EG (2001) Breathing pattern retraining & exercise in COPD. AACN Clin Issues, vol.12
• literature review

Cooper CB (2006) Exercise testing does not have to be complicated. Chronic Respir Dis, 3, 2, 107-108

Dainese R (2004) Effects of physical activity on intestinal gas transit and evacuation in healthy subjects. Am J Med, 116, 536-9
• flatulence may be relieved by gentle bed exercises

Davis AHT (2007) Reliability and validity of the Exercise Self-regulatory Efficacy Scale for individuals with COPD. Heart Lung, 36, 3, 205-16

Dimeo F, Schwartz S, Wesel N et al (2008) Effects of an endurance and resistance exercise program on persistent cancer-related fatigue after treatment. Ann Oncol, 19, 8, 1495-9
annonc.oxfordjournals.org/content/19/8/1495.full.pdf+html
• a 3-week exercise program leads to a substantial improvement of physical performance and reduction of mental and physical fatigue in cancer patients

Drukker M et al (2001) The effects of exercise training in institutionalized elderly people. Phys Ther Rev, 6, 273-85

Eberhardt RT (2002) Exercise for intermittent claudication. J Cardiopulm Rehabi, 22, 199-200
• long-term exercise may reduce ischaemic-related cardiovascular complications

Ernst E (1996) Exercise training and heart failure. Eur J Phys Med Rehabil, 6,161.
• exercise is beneficial in compensated heart failure

Fiatarone MA (1994) Exercise training and nutritional supplementation for physical frailty in very elderly people. New Eng J Med, 330, 1769-75.
• exercise training is effective in very elderly people

Fowler SJ, Singh SJ, Revill S (2004) Reproducibility and validity of the incremental shuttle walking test in patients following coronary artery bypass surgery. Physiotherapy, 91, 22-7
• incremental shuttle walking test relates to cardiorespiratory fitness and correlates with VO2 max

Gigliotti F (2003) Exercise training improves exertional dyspnea in patients with COPD. Chest, 123, 1794–1802
www.chestjournal.org/cgi/content/full/123/6/1794?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=123&firstpage=1794&resourcetype=HWCIT

Glass JM (2004) The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals. J Psychosom Res, 57, 391-398
www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8V-4DN233P-G&_coverDate=10%2F31%2F2004&_alid=327963240&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5096&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f801d3e0377a2ab17fe68fd5ed5e6d03
• some healthy people who have hypoactive function of their stress response unknowingly exercise to augment this response and suppress symptoms; they may be at risk for developing chronic multisymptom illnesses e.g. chronic fatigue syndrome

Griffiths TL (1996) Effects of a structured domiciliary exercise training programme on quality of life and walking tolerance in patients with severe COPD. Eur Resp J, 9(23), 144s
• rehab for severely-impaired patients leads to ¬ exercise tolerance and quality of life

Hamdorf PA (1999) Walking with its training effects on the fitness and activity patterns of 79-91 year old females. Aust NZ J Med, 29, 22-8
• exercise programme increases exercise tolerance in healthy very elderly women

Hautala A et al (2006) Individual differences in the responses to endurance and resistance training. Euro J App Physiol, 96, 5, 535-42, springerlink.metapress.com/(d4yvil45e1gquz45jk0pgjrb)/app/home/contribution.asp?referrer=parent&backto=issue,8,20;journal,4,443;linkingpublicationresults,1:100513,1
• healthy people whose training response is low after endurance training show a marked improvement in cardiorespiratory fitness by resistance training.

Holland AE, Hill C (2008) Physical training for interstitial lung disease. Cochrane Database of Systematic Reviews, 4. Art. No.: CD006322. DOI: 10.1002/14651858.CD006322.pub2
onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD006322/frame.html
• exercise training improves exercise tolerance, breathlessness and QoL for people with interstitial lung disease

Holland AE, Hill CJ, Rasekaba T (2010) Updating the minimal important difference for six-minute walk distance in patients with chronic obstructive pulmonary disease. Arch Phys Med Rehab, 91, 1, 221-25
• a clinically-significantly change in 6MD is 25 meters

Horner D (2001) Chronic heart failure: the challenge for physiotherapists. NZ J Physiother, 29, 15-23
• exercise training is safe for people with CHF

Howe TE, Shea B, Dawson LJ, Downie F, Murray A, Ross C, Harbour RT, Caldwell LM, Creed G. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database of Systematic Reviews 2011, Issue 7. Art. No.: CD000333. DOI: 10.1002/14651858.CD000333.pub2
www2.cochrane.org/reviews/en/ab000333.html
• exercise slightly improves bone mineral density and reduces the chance of fracture.

Hunter J, Singh SJ, Morgan MDL (2006) Objective monitoring of adherence with home exercise training. Physiother, 92, 1, 50-54

Iriberri M, Galdiz JB (2002) Comparison of the distances covered during 3 and 6 min walking test. Resp Med, 96, 812-16
• good correlation between 3 and 6 min walking tests

Janaudis-Ferreira T (2009) Differences in training effects following training with and without supplemental oxygen in patients with COPD. Adv Physiother, 11 (4): 186-92

Keteyian SJ, Piρa IL, Hibner BA (2010) Clinical role of exercise training in the management of patients with chronic heart failure. J Cardiopulm Rehab Prev, 30, 2, 67-76

Kortianou EA (2010) Effectiveness of interval exercise training in patients with COPD. Cardiopulm Phys Ther J, 21, 3, 12–19
www.ncbi.nlm.nih.gov/pmc/articles/PMC2941353/

Lareau SC (2006) Functional status: have we found the gold standard? Chronic Respir Dis, 3, 61-2
• Shuttle test and 6MD are useful to measure walking distance, but not to measure general activities nor upper limb activities

Lazo MG, Filipinas SG, Valdez JE (2003) Compliance with home exercise programs. Arch Phys Med Rehab, 84, E29
• symptom relief and time constraints are the primary factors affecting compliance

Manali ED (2010) MRC chronic dyspnea scale: Relationships with cardiopulmonary exercise testing and 6-minute walk test in idiopathic pulmonary fibrosis patients. BMC Pulm Med, 10, 32. doi:10.1186/1471-2466-10-32
www.biomedcentral.com/1471-2466/10/32/abstract
• in pulmonary fibrosis patients, there’s good correlation between the MRC chronic dyspnoea score and physiological parameters obtained during exercise testing

Mattia ED, Barbarito N, Cirio S et al (2004) Six minute walk test with and without encouragement in severe chronic lung disease patients. Eur Respir J, 24: Suppl. 48, 515s
www.ersnet.org/ers/lr/browse/media.aspx?id_dossier=17643&id_fiche=122823
• patients with severe disease should walk as fast as they like rather than their maximum,
• maximum effort can cause excessive fatigue, dyspnea, tachycardia, and oxygen desaturation without increasing distance walked.

Mejia R (1999) Target dyspnea ratings predict expected oxygen consumption as well as target heart rate values. Am J Respir Crit Care Med, 159, 1485-9
• respiratory patients are often too breathless to reach true maximal HR or VO2max

Mutrie N (2007) Benefits of supervised group exercise programme for women being treated for early stage breast cancer. BMJ, 334, 7592, 517

Nieman DC, Henson DA, Austin MD (2010) Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med, 44, 14

O'Donnell DE et al (1995) The impact of exercise reconditioning on breathlessness in severe chronic airflow limitation. Am J Respir Crit Care Med, 152, 2005-13.
• exercise training reduces acute and chronic breathlessness, and increases exercise tolerance

Olivier FL (1998) Suggested guidelines for the use of exercise with adults in acute care settings. Physiother Can, Spring, 127-36

Peel C, Mossberg KA (1995) Effects of cardiovascular medications on exercise responses. Phys.Ther, 75, 387-96

Pellegrino R (1999) Breathing during exercise in subjects with mild-to-moderate airflow obstruction. J Appl Phys, 87, 1697-1704

Pepera G, McAllister J, Sandercock G (2010) Long-term reliability of the incremental shuttle walking test in clinically stable cardiovascular disease patients. Physiotherapy, 96, 3, 222-7
• practice test not required

Probst VS et al (2004) Mechanisms of improvement in exercise capacity using a rollator in patients with COPD. Chest, 126, 1102-7
www.chestjournal.org/cgi/content/full/126/4/1102?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=probst&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=126&firstpage=1102&resourcetype=HWCIT
• a rollator improves walking distance of patients with COPD through improved ventilatory capacity and/or walking efficiency

Rampulla C (1992) Dyspnea on exercise. Chest, 101, 248S-252S
• fatigue is the main limitation to exercise in COPD, not SOB

Revill SM, Williams J, Sewell L, Collier R, Singh SJ (2009) Within-day repeatability of the endurance shuttle walk test. Physiotherapy, 95, 2, 140-43
www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%2318081%232009%23999049997%231024721%23FLA%23&_cdi=18081&_pubType=J&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6104c9cba5be3f1d9d9b27b93cce6a5d
• practice test not required

Ringbaek TJ (2000) Rehabilitation of patients with COPD. Exercise twice a week is not sufficient! Respir Med, 94, 150-4
• twice-a-week exercise not enough to improve exercise tolerance

Ross RM, Murthy JN, Wollak ID (2010) The six minute walk test accurately estimates mean peak oxygen uptake. BMC Pulm Med, 10, 31. doi:10.1186/1471-2466-10-31
www.biomedcentral.com/1471-2466/10/31/abstract

Rydwik E (2004) Effects of physical training on physical performance in institutionalised elderly patients (70+) with multiple diagnoses. Age Ageing, 33, 13-23
• institutionalised elderly people show improved strength and mobility with exercise training

Sato S (2001) Relationship between exercise tolerance and respiratory pattern and muscular strength of legs in patients with chronic heart failure. J Phys Ther Sci, 14, 47-50
• exercise intolerance is related to respiratory pattern and leg strength in chronic heart failure patients

Selvadurai HC et al (2002) Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis. Pediatr Pulmonol, 33, 194-200
• both aerobic and resistance training benefit people with CF

Schlader ZJ, Mundel T, Barnes MJ (2010) Peak cardiac output in trained males. Br J Sports Med, 44, 14, i21
• training doubles peak cardiac output in males

Smart N (2004) Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity. Am J Med, 116, 693-706

Solway S, Brooks D, Lacasse Y et al (2001) A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest, 119, 256–70
• comparison of 2-min walk test, 6-min walk test, 12-min walk test, self-paced walk test, and shuttle test: 6-min test preferred

Stamatakis E, Weiler R (2010) Prevention of cardiovascular disease: why do we neglect the most potent intervention? Heart, 96, 4, 261-262
heart.bmj.com/content/96/4/261.abstract
• the benefits of physical activity support its use in preventive health care and it should be a serious prescription option for the primary prevention of cardiovascular disease

Stulbarg MS, Carrieri-Kohlman V (2002) Exercise training improves outcomes of a dyspnea self-management program. J Cardiopulm Rehab, 22, 109-21
• exercise helps reduce breathlessness

Tomkinson JL, Bruton A (2009) The 6-minute walk test for patients with bronchiectasis. ACPRC Journal, 41, 16-21
• people with bronchiectasis show same reduction in exercise tolerance as COPD

Ussher MH, Taylor AH, West R, McEwen A (2000) Does exercise aid smoking cessation? Addiction, 95, 199-208
• exercise may aid smoking cessation

Wadell K (2005) Muscle performance in patients with COPD – effects of a physical training programme. Adv Physiother, 7, 51-9
• normal body mass index predicts improvement in muscle performance on exercise training

Wall JC, Bell C, Campbell S (2000) The Timed Get-up-and-Go test revisited: measurement of the component tasks. J Rehabil Res Dev, 37, 109-13
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10847578&dopt=Abstract

Wolf SL, Coogler C, Xu T (1997) Exploring the basis for Tai Chi Chuan as a therapeutic exercise approach. Arch Phys Med Rehab, 78, 886-92

Woodard CM, Berry MJ (2001) Enhancing adherence to prescribed exercise. J Cardiopulm Rehab, 21, 201-9
• review article

Zagol BW, Krasuski RA (2010) Effect of motorized scooters on quality of life and cardiovascular risk. Am J Cardiol, 105, 5, 672-676
www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%234876%232010%23998949994%231746096%23FLA%23&_cdi=4876&_pubType=J&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=804c5791ab0ec479ceb347a83d97f9a7
• interventions such as motorised scooters which reduce activity can increase cardiovascular risk, particularly insulin resistance.


6MD = six-minute distance
ACCP = American College of Chest Physicians
ATS = American Thoracic Society
CF = cystic fibrosis
CHF = chronic heart failure
HR = heart rate
MRC = Medical Research Council
QoL = quality of life
SOB = shortness of breath
VO2max = maximum oxygen consumption