Intensive Care - manual and ventilator hyperinflation
SEE ALSO – ICU – Physiotherapy Overview

Allen GB, Suratt BT, Rinaldi L, Petty JM, Bates JH (2006) Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol, 291, L710–L717
www.ncbi.nlm.nih.gov/pubmed/16698851
• low tidal volume ventilation protects against ventilator-induced lung injury but can promote atelectasis
• periodic deep inflation can open alveoli, but if delivered too frequently may cause damage by repeated overdistention
frequent ventilator deep breaths can safely improve gas exchange and lung mechanics and may confer protection from biotraum

Anning L, Paratz J, Wong WP et al (2003) Effect of manual hyperinflation on haemodynamics in an animal modal. Respir Care, 8, 3, 155-63
www3.interscience.wiley.com/cgi-bin/abstract/112510534/ABSTRACT
• mechanism of effect on manual hyperinflation on cardiac output

Barke M, Eales CJ (1994) Ambubagging as a therapeutic technique. S.African J.Phys, 50, 26-7

Barker M, Adams S (2002) An evaluation of a single chest physiotherapy treatment on mechanically ventilated patients with acute lung injury. Physiother Res Int, 7, 3, 157-69
www3.interscience.wiley.com/journal/112501201/abstract
• PaO2:FiO2 ratio did not alter significantly with (a) suction, (b) positioning and suction, (c) positioning, MH and suction.

Berney S, Denehy L (2002) A comparison of the effects of manual and ventilator hyperinflation on static lung compliance and sputum production. Physiother Res Internat, 7, 100-108
• both methods improve lung compliance and clear secretions

Berney S, Denehy L (2003) The effect of physiotherapy on oxygen consumption and haemodynamics in patients who are critically ill. Austr J Physiother, 49, 99-105
ajp.physiotherapy.asn.au/AJP/vol_49/2/AustJPhysiotherv49i2Berney.pdf
• Sensible physiotherapy does not upset metabolic or haemodynamic variables;
• MHI increases compliance, resolves atelectasis and clear secretions
• Corrects other articles mistakenly asserting that PT can be dangerous:

Berney S, Denehy L, Pretto J (2004) Head-down tilt and manual hyperinflation enhance sputum clearance in patients who are intubated and ventilated. Aust J Physiother, 50, 9–14
www.physiotherapy.asn.au/AJP/50-1/AustJPhysiotherv50i1Berney.pdf
• during manual hyperinflation, a head-down tilt increases sputum production

Choi JS-P, Jones A Y-M (2005) Effects of manual hyperinflation and suctioning on respiratory mechanics in mechanically ventilated patients with ventilator-associated pneumonia. Austr J Physiother, 51, 25-30
www.physiotherapy.asn.au/AJP/vol_51/1/AustJPhysiotherv51i1Choi.pdf
• manual hyperinflation improves lung compliance in people with ventilator-associated pneumonia

Clapham L, Harrison J, Raybould T (1995) A multidisciplinary audit of manual hyperinflation. Int Crit Care Nurs, 11, 265-71
www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WGN-4DK6DNY-N&_user=10&_handle=V-WA-A-W-AE-MsSAYVA-UUW-U-AAVWCVBYEC-AAVUAWVZEC-ZCYCZZZVY-AE-U&_fmt=summary&_coverDate=10%2F31%2F1995&_rdoc=5&_orig=browse&_srch=%23toc%236827%231995%23999889994%23567056!&_cdi=6827&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3cb88e001e92e2738f31b220c875dc88
• audit leading to a standardised technique

Claxton BA, Morgan P, Mckeague H (2003) Alveolar recruitment strategy improves arterial oxygenation after cardiopulmonary bypass. Anaesthesia, 58, 111-16

Constantin JM, Futier E (2010) A recruitment maneuver increases oxygenation after intubation of hypoxemic intensive care unit
patients. Crit Care, 14:R76
www.biomedcentral.com/content/pdf/cc8989.pdf
• randomised controlled study showing how a recruitment maneuver (CPAP of 40 cmH2O over 30 seconds) following intubation in hypoxemic patients improved oxygenation, without adverse effects.

Corley M et al (1993) The myth of 100% oxygen delivery through manual resuscitation bags. J Emerg Nurs, 19, 45-4
• different bags have different FIO2

Davies N, Igo S (2004) Manual hyperinflation: a survey investigating the use of current best evidence. ACPRC Journal, 36, 8-17
• a manometer in the circuit should be mandatory

Denehy L (1999) The use of manual hyperinflation in airways clearance. Eur Resp J, 14, 958-65
erj.ersjournals.com/cgi/reprint/14/4/958?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1140033961325_2670&FIRSTINDEX=0&sortspec=relevance&volume=14&firstpage=958&resourcetype=1&journalcode=erj
• includes a further exhortation to use a manometer

Dueck R (2006) Alveolar recruitment versus hyperinflation: A balancing act. Curr Opin Anaesthesiol, 19, 6, 650-4.
www.ncbi.nlm.nih.gov/pubmed/17093370?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=4&log$=relatedreviews&logdbfrom=pubmed
• PEEP levels must be high enough to minimise recruitment/derecruitment cycling.
• balancing recruitment versus overdistension may require thoracic tomography.

Dyhr T et al (2002) Effects of lung recruitment maneuvre and PEEP on lung volume, respiratory mechanics and alveolar gas mixing in patients ventilated after cardiac surgery. Acta Anaesthesiol Scand, 46, 717-25
www.blackwell-synergy.com/doi/abs/10.1034/j.1399-6576.2002.460615.x
• maintenance of PEEP with manual hyperinflation

Dyhr T et al (2003) Lung recruitment manoeuvres are effective in regaining lung volume and oxygenation after open endotracheal suctioning in acute respiratory distress syndrome. Crit Care, 7(1): 55–62
ccforum.com/content/7/1/55
• MH is effective in regaining lung volume after suction

Eaton JM (1984) Adult manual resuscitators. Br J Hosp Med, 31, 67-70
• max safe pressure is 70 cmH2O in normal lungs

Ellis ER, Redfern J, Rusterholtz B (1999) The effects of feedback on the performance of manual hyperinflation by physiotherapists. WCPT Proc. p.31
• manometer ensures effective and safe pressures

Gammon RB (1991) Pulmonary interstitial emphysema in mechanically ventilated patients. Am Rev Resp Dis, 143, 4, A693
• barotrauma on x-ray - mediastinal emphysema, interstitial emphysema

Gammon RB (1992) Pulmonary barotrauma in IPPV. Chest, 102, 568-72
www.chestjournal.org/cgi/content/abstract/102/2/568
• incidence and risk factors for pneumothorax and pneumomediastinum

Goldstein (1989) The role of in-line manometers in minimizing peak and mean airway pressure in newborn infants. Respir Care, 34, 23-7.

Griffiths R (2000) Breathing circuits and their uses. Br J Periop Nurs, 10, 55-9

Haake R et al (1987) Barotrauma. Chest, 91, 608-13
• unevenly damaged lungs are at risk

Halter JM (2003) Positive End-Expiratory Pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Respir Crit Care Med, 167, 1620-26
ajrccm.atsjournals.org/cgi/content/full/167/12/1620
• effect of recruitment maneuver using peak pressure of 45 cmH2O and PEEP of 35 cmH2O for 1 minute, followed by PEEP of 5 or 10 cmH2O

Hess D et al (1994) Imposed work and oxygen delivery during spontaneous breathing with adult disposable manual ventilators. Anesthesiol, 81, 1256-63
• breathing spontaneously through the bag increases the work of breathing

Hess DR, Bigatello LM (2002) Lung recruitment: the role of recruitment maneuvers. Respir Care, 47, 308-17
www.rcjournal.com/contents/03.02/03.02.0308.asp
• ‘open lung strategies’ by extra PEEP, sustained inflation, stepwise inflation, sighs & spontaneous breathing

Hicky J (2006) Manually ventilating & suctioning in-line with a SensorMedics 3100B high frequency oscillatory ventilator bench test. AARC Conference, Texas
www.cardinal.com/mps/focus/respiratory/abstracts/abstracts/ab2006/OF-06-157.asp
• method for manual hyperinflation and suction without losing airway pressure with HFO

Hila J, Ellis E (2002) Feedback withdrawal and changing compliance during manual hyperinflaiton. Physiother Res Internat, 7, 53-64
• pressure manometer recommended for safe and effective practice

Hillman K, Albin M (1986) Pulmonary barotrauma during cardiopulmonary resuscitation. Crit Care Med, 14, 606-9
• barotrauma is inevitable at 90 cmH20 pressure

Hodgson C et al (1996) The acute cardiorespiratory effects of manual lung hyperinflation. Eur Resp J, 9 (suppl.23), 37s
• MH increases lung compliance and SaO2

Hodgson C et al (2000) An investigation of the early effects of manual lung hyperinflation in critically ill patients. Anaesth Int Care, 28, 255-61
• MH increases sputum clearance

Jantz MA (1994) Pneumothorax and barotrauma. Clin Chest Med, 15, 1, 75-92
• identification of early barotrauma on x-ray

Jellema WT et al (2000) Haemodynamic effects of intermittent manual hyperinflation in patients with septic shock. Heart Lung, 29, 356-66
• risk of haemodynamic compromise with MH is relatively small

Jones A et al (1992) Peak expiratory flow rates produced with the Laerdal and Mapleson-C bagging circuits. Austr Physiotherapy J, 38, 211-15

Jones A, Hutchinson RC (1992) Effects of bagging and percussion on total static compliance of the respiratory system. Physiotherapy, 78, 661-66
• percussion/vibs/suction increases heart rate and BP, MH increases lung compliance

Lapinsky SE et al (1997) Safety and efficacy of a sustained inflation maneuver for alveolar recruitment. Chest, 112, 126S
• sustained inflations at 30-40 cmH2O for 20 secs are safe through ventilator

Lapinsky SE (2003) Recruitment and retention of lung volume. Crit Care, 7, 9-10
ccforum.com/content/7/1/9
• editorial relating to Dyhr et al (2003), above

Maa S-H, Hung T-J, Hsu K-H (2005) Manual hyperinflation improves alveolar recruitment in difficult-to-wean patients. Chest, 128, 2714-21.
chestjournal.chestpubs.org/content/128/4/2714.full?sid=c3f28d99-318b-4fa9-b66e-916a84952698
• manual hyperinflation significantly recruits collapsed alveoli

Maxwell L, Ellis E (1998) Secretion clearance by manual hyperinflation. Physiother Th Pract, 14, 89-97

Maxwell L, Ellis ER (2002) The effects of three manual hyperinflation techniques on pattern of ventilation in a test lung. Anaesth Int Care, 30, 283-8
www.aaic.net.au/
• how different techniques affect pressure and volume

Maxwell LJ, Ellis ER (2003) The effect of circuit type, volume delivered and rapid release on flow rates during manual hyperinflation. Austr J Physiother, 49, 31-8
• assessment of different bags and different techniques

Maxwell LJ, Ellis ER (2004) Effect of maintaining bag compression during manual hyperinflation. Austr J Physiother, 50, 49
www.physiotherapy.asn.au/AJP/50-1/AustJPhysiotherv50i1Maxwell.pdf

McCarren B (1998) Description of manual hyperinflation in intubated patients with atelectasis. Physiother Theory Pract, 14, 199-210

Nielsen J (2006) Central hemodynamics during lung recruitment maneuvers at hypovolemia, normovolemia and hypervolemia. Int Care Med, 32, 4, 585-94
www.springerlink.com/(accux3esn5ttldic1i3hpc55)/app/home/contribution.asp?referrer=parent&backto=issue,16,37;journal,4,297;linkingpublicationresults,1:100428,1
• lung recruitment maneuvers significantly decreased cardiac output at hypovolemia; hypervolemia partly counteracted this compromise. Also a marked right-ventricular dysfunction was found

Novak RA et al (1987) Do periodic hyperinflations improve gas exchange in patients with hypoxemic respiratory failure? Crit Care Med, 15, 1081-5
• pressure of 40 cmH2O is required to reverse venous admixture.
• MH can upset haemodynamics

Ntoumenopoulos G (2005) Indications for manual lung hyperinflation in the mechanically ventilated patient with COPD. Chron Respir Dis, 2: 199-207

Ntoumenopoulos G, Gild A (1998) The effect of manual lung hyperinflation and postural drainage on pulmonary complications. Anaesth Int Care, 26, 492-6
www.aaic.net.au/ (summary available)
• trend towards reduced nosocomial pneumonia in patients receiving manual hyperinflation and postural drainage

Nunn JF et al (1965) Factors influencing the arterial oxygen tension during anaesthesia with artificial ventilation. Br J Anaesth. 37, 898-914
• sustained pressure of 40 cmH2O is required to reverse atelectasis

Paratz et al (2002) Effect of manual hyperinflation on hemodynamics, gas exchange, and respiratory mechanics in ventilated patients. J Int Care Med, 17, 317-324
jic.sagepub.com/cgi/content/abstract/17/6/317?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=17&firstpage=317&resourcetype=HWCITMHI improves lung mechanics and gas exchange without impairing the cardiovascular system

Patman S, Jenkins S, Smith K (2001) Manual hyperinflation: consistency and modification of the technique by physiotherapists. Phys Res Int, 6, 106-17

Patman S, Jenkins S (1998) Cardiovascular responses to manual hyperinflation in postoperative coronary artery surgery. Physiother Theory Pract, 14, 5-12

Patman S, Jenkins S, Stiller K (2000) Manual hyperinflation: effects on respiratory parameters. Physiother Res Internat, 5(3), 157-71
• MH improves lung compliance, (A-a)PO2, PaO2/FiO2

Pearson SJ (1996) Peak airway pressures exerted during manual hyperinflation. Br J Ther Rehab, 3, 261-6

Redfern J, Ellis E, Holmes W (2001) The use of a pressure manometer enhances students physiotherapists performance during manual hyperinflation. Austr J Physiother, 47, 121-31
ajp.physiotherapy.asn.au/AJP/vol_47/2/AustJPhysiotherv47i2Redfern.pdf
• manometer provides effective feedback

Reick CW (1996) Auto-PEEP associated with excessive oxygen flow through five manual resuscitators. Respir Care, 41, 1009-12
• advice for MH with slow flow rate to avoid intrinsic PEEP

Robson WP (1998) To bag or not to bag? Int Crit Care Nurs. 14, 239-43
www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WGN-4DHNT8N-5S&_user=10&_handle=V-WA-A-W-E-MsSAYZA-UUA-U-AAVWEZBUBA-AAVUCVBYBA-ZZEUEBEUE-E-U&_fmt=summary&_coverDate=10%2F31%2F1998&_rdoc=5&_orig=browse&_srch=%23toc%236827%231998%23999859994%23540603!&_cdi=6827&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7e8b20d0d97301ecbc59ea21082170d3
• literature review

Rothen HU, Neumann P, Berglund JE et al (1999) Dynamics of re-expansion of atelectasis during general anaesthesia. Br J Anaesth, 82, 551-6
• pressure of 40 cmH2O (i.e. to vital capacity) eliminates atelectasis

Rusterholz B, Ellis D (1998) The effect of lung compliance and experience on manual hyperinflation. Austr J Physiother, 44, 23-8

Silbergleit R et al (1996) Sudden severe barotrauma from self-inflating bag-valve devices. J Trauma, 40, 320-2
www.jtrauma.com/pt/re/jtrauma/abstract.00005373-199602000-00031.htm;jsessionid=D4ysC2SXIab2U16fBKL0MjvTvi0Y9gDgOBs1XPUoObXLcAYn1ve4!-477899252!-949856144!9001!-1
• bag with reservoir may push up pressures if valve blocked

Singer M, Vermaat J (1994) Hemodynamic effects of manual hyperinflation in critically ill patients. Chest, 106, 1182-7
chestjournal.chestpubs.org/content/106/4/1182.full.pdf+html?sid=8887ec47-ee48-4fb9-acb3-b621a795883b
• MH can increase or decrease BP, but cardiac output is consistently reduced and takes up to 15 mins to recover

Sommers MS (1991) Potential for injury. Heart Lung, 20, 287-95.
• max safe pressure is 60 cmH2O in normal lungs

Stone KS et al (1991) The effect of lung hyperinflation and endotracheal suctioning on cardiopulmonary haemodynamics. Nurs Res, 40, 76-80
• mechanism of how MH can increase BP

Tusman G, Bohm SH, Tempra A et al (2003) Effects of recruitment maneuver on atelectasis in anesthetized children. Anesthiol, 98, 14-22
www.anesthesiology.org/pt/re/anes/fulltext.00000542-200301000-00006.htm;jsessionid=D4zrItG5sPaPQCx2FEttl6IefE6ttfsZtLZ3K1bXSCdbMe62SfjW!-477899252!-949856144!9001!-1
• atelectasis was reduced in children given manual hyperinflation with peak pressure of 40 cmH2O and PEEP of 15 cmH2O for 10 breaths





ACPRC = Association of Chartered Physiotherapists in Respiratory Care
ARDS = acute respiratory distress syndrome
CPAP = continuous positive airways pressure
FIO2 = fraction of inspired oxygen
MH = manual hyperinflation
PaO2:FiO2 = arterial oxygen to fraction of inspired oxygen ratio
PEEP = positive end-expiratory pressure
WCPT = World Confederation of Physical Therapy